Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR

Md. Hafizur Rahman; Nashid Amir; Md. Anisur Rahman; Zakir Hossain ASM

doi:doi:10.11648/j.ijmi.20210904.12

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Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR

Md. Hafizur Rahman, Nashid Amir, Md. Anisur Rahman, Zakir Hossain ASM

Published in International Journal of Medical Imaging (Volume 9, Issue 4)

Received: 1 August 2021 Accepted: 4 October 2021 Published: 30 October 2021

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Abstract

Background & purpose: This study was designed to evaluate the diagnostic performance of HRCT scan of chest in comparison to RT-PCR in the diagnosis of coronavirus disease 2019 (COVID-19). Materials & Methods: This study was conducted in the Department of Radiology & Imaging, Rajshahi Medical College Hospital, Rajshahi that included 150 patients over a period of eight months from April, 2020 to December, 2020. Using RT-PCR as the reference standard, the performance of HRCT scan of chest in the diagnosis of COVID-19 was assessed. In addition, the common HRCT findings, CT severity, demographic distribution of the disease were also analyzed. Results: The mean age of patients was 51.8±14.5 years, age range was from 24 to 82 years. There was a male predominance with 1.58:1. Cough (86.7%) &dyspnoea (74.7%) were the predominant clinical symptoms. Commonest CT features were GGO (97.1%) & GGO with consolidation (49.0%) followed by fibrosis (48%). Majority of the patients had all five lobes involved (51%) & CT severity showed majority with 25-50% involvement (28%) followed by 50-75% involvement in 22.3% patients. Specificity, sensitivity, positive predictive value, negative predictive value, accuracy & reliability were 97%, 43.7%, 93.5%, 63.6%, 91.3% & 0.88 respectively. Conclusion: HRCT chest has a very high sensitivity for diagnosis of COVID-19. HRCT chest should be considered as complementary to RT-PCR & a primary tool for detection of COVID-19 in this pandemic situation.

Published in	International Journal of Medical Imaging (Volume 9, Issue 4)
DOI	10.11648/j.ijmi.20210904.12
Page(s)	167-172
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HRCT, RT-PCR, COVID-19, Diagnostic Performance, CT Severity, Sensitivity

References

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[2]	Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, Zeng B, Li Z, Li X, Li H. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? European journal of radiology 2020: 126: 108961.
[3]	Guan W., Ni Z., Hu Y. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 2020 doi: 10.1056/NEJMoa2002032.
[4]	Xie X., Zhong Z., Zhao W., Zheng C., Wang F., Liu J. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology. 2020 doi: 10.1148/radiol.2020200343.
[5]	Tao Ai, Zhenlu Yang, Hongyan Hou, Chenao Zhan, Chong Chen, Wenzhi Lv, Qian Tao, Ziyong Sun, Liming Xia. Original research; Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Thoracic Imaging Radiology; Radiology 2020; 296: E32–E40.
[6]	Ashraf V, Chaudhry S, Yousaf KR, Chatha AA, Khalid A. Spectrum of High Resolution Computed Tomography Findings in COVID-19 Infection. Annals of King Edward Medical University, 2020, 26 (Special Issue), 187-191.
[7]	Alam SZ, Muid SMAA, Akhter A, Rahman AKMS, Emran MA, Mostakim MTA. HRCT Chest Evaluation of COVID-19 Patients: Experience in Combined Military Hospital, Dhaka, Bangladesh. Journal of Bangladesh College of Physicians and Surgeons; Vol. 38, COVID-19 (Supplement Issue), July 2020.
[8]	Chan J. F., Yip C. C., To K. K. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J. Clin. Microbiol. 2020.
[9]	Fang Y., Zhang H., Xie J. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology. 2020.
[10]	Ai T., Yang Z., Hou H. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 2020.

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APA Style

Md. Hafizur Rahman, Nashid Amir, Md. Anisur Rahman, Zakir Hossain ASM. (2021). Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. International Journal of Medical Imaging, 9(4), 167-172. https://doi.org/10.11648/j.ijmi.20210904.12

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ACS Style

Md. Hafizur Rahman; Nashid Amir; Md. Anisur Rahman; Zakir Hossain ASM. Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. Int. J. Med. Imaging 2021, 9(4), 167-172. doi: 10.11648/j.ijmi.20210904.12

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AMA Style

Md. Hafizur Rahman, Nashid Amir, Md. Anisur Rahman, Zakir Hossain ASM. Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. Int J Med Imaging. 2021;9(4):167-172. doi: 10.11648/j.ijmi.20210904.12

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@article{10.11648/j.ijmi.20210904.12,
  author = {Md. Hafizur Rahman and Nashid Amir and Md. Anisur Rahman and Zakir Hossain ASM},
  title = {Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR},
  journal = {International Journal of Medical Imaging},
  volume = {9},
  number = {4},
  pages = {167-172},
  doi = {10.11648/j.ijmi.20210904.12},
  url = {https://doi.org/10.11648/j.ijmi.20210904.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20210904.12},
  abstract = {Background & purpose: This study was designed to evaluate the diagnostic performance of HRCT scan of chest in comparison to RT-PCR in the diagnosis of coronavirus disease 2019 (COVID-19). Materials & Methods: This study was conducted in the Department of Radiology & Imaging, Rajshahi Medical College Hospital, Rajshahi that included 150 patients over a period of eight months from April, 2020 to December, 2020. Using RT-PCR as the reference standard, the performance of HRCT scan of chest in the diagnosis of COVID-19 was assessed. In addition, the common HRCT findings, CT severity, demographic distribution of the disease were also analyzed. Results: The mean age of patients was 51.8±14.5 years, age range was from 24 to 82 years. There was a male predominance with 1.58:1. Cough (86.7%) &dyspnoea (74.7%) were the predominant clinical symptoms. Commonest CT features were GGO (97.1%) & GGO with consolidation (49.0%) followed by fibrosis (48%). Majority of the patients had all five lobes involved (51%) & CT severity showed majority with 25-50% involvement (28%) followed by 50-75% involvement in 22.3% patients. Specificity, sensitivity, positive predictive value, negative predictive value, accuracy & reliability were 97%, 43.7%, 93.5%, 63.6%, 91.3% & 0.88 respectively. Conclusion: HRCT chest has a very high sensitivity for diagnosis of COVID-19. HRCT chest should be considered as complementary to RT-PCR & a primary tool for detection of COVID-19 in this pandemic situation.},
 year = {2021}
}

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TY  - JOUR
T1  - Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR
AU  - Md. Hafizur Rahman
AU  - Nashid Amir
AU  - Md. Anisur Rahman
AU  - Zakir Hossain ASM
Y1  - 2021/10/30
PY  - 2021
N1  - https://doi.org/10.11648/j.ijmi.20210904.12
DO  - 10.11648/j.ijmi.20210904.12
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 167
EP  - 172
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20210904.12
AB  - Background & purpose: This study was designed to evaluate the diagnostic performance of HRCT scan of chest in comparison to RT-PCR in the diagnosis of coronavirus disease 2019 (COVID-19). Materials & Methods: This study was conducted in the Department of Radiology & Imaging, Rajshahi Medical College Hospital, Rajshahi that included 150 patients over a period of eight months from April, 2020 to December, 2020. Using RT-PCR as the reference standard, the performance of HRCT scan of chest in the diagnosis of COVID-19 was assessed. In addition, the common HRCT findings, CT severity, demographic distribution of the disease were also analyzed. Results: The mean age of patients was 51.8±14.5 years, age range was from 24 to 82 years. There was a male predominance with 1.58:1. Cough (86.7%) &dyspnoea (74.7%) were the predominant clinical symptoms. Commonest CT features were GGO (97.1%) & GGO with consolidation (49.0%) followed by fibrosis (48%). Majority of the patients had all five lobes involved (51%) & CT severity showed majority with 25-50% involvement (28%) followed by 50-75% involvement in 22.3% patients. Specificity, sensitivity, positive predictive value, negative predictive value, accuracy & reliability were 97%, 43.7%, 93.5%, 63.6%, 91.3% & 0.88 respectively. Conclusion: HRCT chest has a very high sensitivity for diagnosis of COVID-19. HRCT chest should be considered as complementary to RT-PCR & a primary tool for detection of COVID-19 in this pandemic situation.
VL  - 9
IS  - 4
ER  -

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Author Information

Md. Hafizur Rahman

Department of Radiology & Imaging, Rajshahi Medical College, Rajshahi, Bangladesh
Nashid Amir

Department of Radiology & Imaging, Rajshahi Medical College, Rajshahi, Bangladesh
Md. Anisur Rahman

Department of Radiology & Imaging, Rajshahi Medical College, Rajshahi, Bangladesh
Zakir Hossain ASM

Department of Radiology & Imaging, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh

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APA Style

Md. Hafizur Rahman, Nashid Amir, Md. Anisur Rahman, Zakir Hossain ASM. (2021). Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. International Journal of Medical Imaging, 9(4), 167-172. https://doi.org/10.11648/j.ijmi.20210904.12

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ACS Style

Md. Hafizur Rahman; Nashid Amir; Md. Anisur Rahman; Zakir Hossain ASM. Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. Int. J. Med. Imaging 2021, 9(4), 167-172. doi: 10.11648/j.ijmi.20210904.12

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AMA Style

Md. Hafizur Rahman, Nashid Amir, Md. Anisur Rahman, Zakir Hossain ASM. Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR. Int J Med Imaging. 2021;9(4):167-172. doi: 10.11648/j.ijmi.20210904.12

Copy | Download

@article{10.11648/j.ijmi.20210904.12,
  author = {Md. Hafizur Rahman and Nashid Amir and Md. Anisur Rahman and Zakir Hossain ASM},
  title = {Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR},
  journal = {International Journal of Medical Imaging},
  volume = {9},
  number = {4},
  pages = {167-172},
  doi = {10.11648/j.ijmi.20210904.12},
  url = {https://doi.org/10.11648/j.ijmi.20210904.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20210904.12},
  abstract = {Background & purpose: This study was designed to evaluate the diagnostic performance of HRCT scan of chest in comparison to RT-PCR in the diagnosis of coronavirus disease 2019 (COVID-19). Materials & Methods: This study was conducted in the Department of Radiology & Imaging, Rajshahi Medical College Hospital, Rajshahi that included 150 patients over a period of eight months from April, 2020 to December, 2020. Using RT-PCR as the reference standard, the performance of HRCT scan of chest in the diagnosis of COVID-19 was assessed. In addition, the common HRCT findings, CT severity, demographic distribution of the disease were also analyzed. Results: The mean age of patients was 51.8±14.5 years, age range was from 24 to 82 years. There was a male predominance with 1.58:1. Cough (86.7%) &dyspnoea (74.7%) were the predominant clinical symptoms. Commonest CT features were GGO (97.1%) & GGO with consolidation (49.0%) followed by fibrosis (48%). Majority of the patients had all five lobes involved (51%) & CT severity showed majority with 25-50% involvement (28%) followed by 50-75% involvement in 22.3% patients. Specificity, sensitivity, positive predictive value, negative predictive value, accuracy & reliability were 97%, 43.7%, 93.5%, 63.6%, 91.3% & 0.88 respectively. Conclusion: HRCT chest has a very high sensitivity for diagnosis of COVID-19. HRCT chest should be considered as complementary to RT-PCR & a primary tool for detection of COVID-19 in this pandemic situation.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Diagnostic Performance of HRCT Scan of Chest in the Evaluation of COVID-19 Pneumonia: Comparison to RT-PCR
AU  - Md. Hafizur Rahman
AU  - Nashid Amir
AU  - Md. Anisur Rahman
AU  - Zakir Hossain ASM
Y1  - 2021/10/30
PY  - 2021
N1  - https://doi.org/10.11648/j.ijmi.20210904.12
DO  - 10.11648/j.ijmi.20210904.12
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 167
EP  - 172
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20210904.12
AB  - Background & purpose: This study was designed to evaluate the diagnostic performance of HRCT scan of chest in comparison to RT-PCR in the diagnosis of coronavirus disease 2019 (COVID-19). Materials & Methods: This study was conducted in the Department of Radiology & Imaging, Rajshahi Medical College Hospital, Rajshahi that included 150 patients over a period of eight months from April, 2020 to December, 2020. Using RT-PCR as the reference standard, the performance of HRCT scan of chest in the diagnosis of COVID-19 was assessed. In addition, the common HRCT findings, CT severity, demographic distribution of the disease were also analyzed. Results: The mean age of patients was 51.8±14.5 years, age range was from 24 to 82 years. There was a male predominance with 1.58:1. Cough (86.7%) &dyspnoea (74.7%) were the predominant clinical symptoms. Commonest CT features were GGO (97.1%) & GGO with consolidation (49.0%) followed by fibrosis (48%). Majority of the patients had all five lobes involved (51%) & CT severity showed majority with 25-50% involvement (28%) followed by 50-75% involvement in 22.3% patients. Specificity, sensitivity, positive predictive value, negative predictive value, accuracy & reliability were 97%, 43.7%, 93.5%, 63.6%, 91.3% & 0.88 respectively. Conclusion: HRCT chest has a very high sensitivity for diagnosis of COVID-19. HRCT chest should be considered as complementary to RT-PCR & a primary tool for detection of COVID-19 in this pandemic situation.
VL  - 9
IS  - 4
ER  -

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